One thing you should probably just do asap is to disable atime , mount your filesystem where the files reside on with the
noatime option - this will reduce drive IO quite a bit - you likely don't need the access time of files to be updated –  nos Jan 29 '11 at 19:56 I found this tutorial, howtoforge.com/… and I would have to add the noatime to /dev/sda5.
This site even talks about "nodiratime" too which means: Do not update directory inode access times on this filesystem sites.google.com/site/wikirolanddelepper/recommanded-tuning/…
Along with the 
noatime option @nos mentioned, you might want to consider the following:- in nginx, set 
access_log off;-- commenting it out doesn't do anything; you need to actively disable it. - reduce the number of worker processes. nginx doesn't benefit from more than one worker per CPU.
 tcp_nodelay on;will help nginx serve files quicker on "live" connections.- try playing with 
tcp_nopush. I've found it best to switch it on, but YMMV. - set 
if_modified_sincetobefore; it will allow nginx to send304 Not Modifiedheaders rather than re-serving the content. - play with the 
open_file_cachesettings - reduce the 
send_timeoutso nginx can free-up stale client connections. 
As for the rest of your system:
hdparamsettings. lots of tutorials to help you online, hdparam tweaks will get the best out of your disks.- tweak your 
socketperformance settings - recompile the kernel with a reduced timer frequency. the default is 1000 Hertz which is great for desktop machines providing video but isn't all that good for servers where a value of 100-250 might be more appropriate
 - disable services like cups and bluetooth
 
However, I believe the best performance boost would be putting Varnish in front of your nginx server and using it rather than nginx for serving static files. It will keep "hot" files in memory better than nginx can, so that there's little/no disk use for your most-served content.
The main thing however is to monitor EVERYTHING -- don't go with your gut, know what your server is doing and where your bottlenecks are.
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